Human body●●●●●Difficulty 1 of 5

Why does a cut turn red, hot and swollen?

A Roman writer listed the four signs of a wound going red and swelling nearly two thousand years before anyone knew why it happened.

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A cut turns red, hot and swollen because your blood vessels are reacting on purpose. The instant skin breaks, nearby cells release chemical signals. Those signals widen the local blood vessels, so more blood flows in and the skin turns red and warm. The vessel walls also get leakier, so fluid seeps into the tissue and it swells. One of the signal chemicals makes nerves more sensitive, which is why the spot hurts. This whole reaction is called inflammation. It isn't damage, it's defense.

What happens under a swollen cut
  1. Step 1: Alarm signals

    Injured cells release chemical mediators

  2. Step 2: Vessels widen

    More blood flows in: redness and heat

  3. Step 3: Vessels leak

    Fluid seeps into tissue: swelling

  4. Step 4: Nerves react

    Bradykinin raises pain sensitivity

  5. Step 5: Cells arrive

    Neutrophils and macrophages slip into the tissue

A Roman writer named Aulus Cornelius Celsus wrote these signs down almost two thousand years ago, in a medical book called De Medicina. He listed heat, pain, redness and swelling, a group of four now called the Celsus tetrad. A fifth sign, loss of function, was added much later by other physicians. Doctors still use this same list today, even though Celsus had no idea what was happening inside the tissue.

Inflammation belongs to the innate immune system, the body's fast, general-purpose defense that reacts the same way to almost any threat. The widened, leaky vessels let defending cells leave the blood and crowd into the injured tissue. The reaction is a balancing act: too little of it, and an infection can spread unchecked; too much of it, especially if it drags on for a long time, is linked to diseases such as atherosclerosis and osteoarthritis.

Quiz me

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  1. 1.Why does skin around a fresh cut turn red and feel warm?
  2. 2.What did Celsus's four classical signs of inflammation describe?
  3. 3.Why is inflammation classified as part of innate rather than adaptive immunity?

Recap

Chemical signals widen and loosen blood vessels at an injury, and that widening and leaking is what produces heat, redness, swelling and the pull of defending cells into the tissue.

Surprising fact · The Roman writer Celsus recorded the four classical signs of inflammation around two thousand years before scientists explained that widened, leaky blood vessels cause them.

Sources (3)

No source, no claim. Every fact in this lesson (14 claims) cites at least one of these.

  1. [1]Inflammation · Wikipedia
  2. [2]Aulus Cornelius Celsus · Wikipedia
  3. [3]Innate immune system · Wikipedia
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